张治军

作者: 时间:2022-03-04

张治军 博士

讲师,硕士生导师

一、 工作学习经历

2006-2010 西南交通大学生命科学与工程学院,理学学士

2010-2013 4066金沙(中国)有限公司,医学硕士

2013-2015 中国科学院昆明植物研究所,研究实习员

2015-2018 中国科学院昆明植物研究所,理学博士

2018-2021 4066金沙(中国)有限公司,博士后

2021-至今 4066金沙(中国)有限公司,讲师

二、 研究领域

传统药用植物中活性成分的功能研究是目前主要的研究方向。主要的研究内容为药用植物中抗炎、抗病毒活性成分的定向挖掘;高效、低毒活性化合物的结构修饰、构效关系及作用机制。

三、 开设的课程

《天然药物化学》和《基础有机化学》

四、 代表性论文

1. Du, X.-Y.; Li, G.-X.; Chen, X.-Q.; Li, R.-T.;Zhang, Z.-J.*, Pterocarpans and 2-arylbenzofurans fromSophora flavescensAiton and their chemotaxonomic significance.Biochemical Systematics and Ecology2022, 100 (1), 104357.

2. Zhang, Z.-J.; Zhou, X.; Li, D.; Chen, Y.; Xiao, W.-W.; Li, R.-T.*; Shao, L.-D.*, Aerobic copper-catalyzed intramolecular cascade oxidative isomerization/[4+4] cyclization of 2,2′-disubstituted stilbenes.Journal of Organic Chemistry2021, 86 (11), 7609-7624.

3. Zhang, Z.-J.; Dong, S.-W.; Gao, D.-D.; Du, X.-Y.; Xie, Y.-Q.; Xia, X.-S.; Li, R.-T.*, Unusual matrine–adenine hybrids isolated fromSophora davidiiand their inhibitory effects on human cytomegalovirus.Phytochemistry2021, 190, 112842.

4. Zhang, Y.-Y.; Liu, D.; Ye, R.-R.; Chen, X.-Q.; Li, R.-T.;Zhang, Z.-J.*, Anti-inflammatory quinolizidine alkaloids from the aerial parts ofSophora tonkinensis.Phytochemistry Letters2021, 45, 121-125.

5. Xie, Y.-Q.; Fan, W.-T.; Chen, X.-Q.; Li, R.-T.;Zhang, Z.-J.*, Chemical constituents fromLaggera pterodonta.Biochemical Systematics and Ecology2021, 94 (2), 104222.

6. Xie, Y.-Q.; Du, X.-Y.; Liu, D.; Chen, X.-Q.; Li, R.-T.;Zhang, Z.-J.*, Chemical constituents fromLaggera pterodontaand their anti-inflammatory activitiesin vitro.Phytochemistry Letters2021, 43, 126-129.

7. Li, G.-X.; Du, X.-Y.; Xie, Y.-Q.; Liu, D.; Li, R.-T.;Zhang, Z.-J.*, Flavescenols A and B, two lavandulylated acylphloroglucinols fromSophora flavescens.Phytochemistry Letters2021, 43, 179-183.

8. Zhang, Z.-J.; Zhu, Q.-F.; Wu, X.-D.; Zhao, Q.-S.*, Phlegmadines B and C, twoLycopodiumalkaloids with 6/5/5/5/7 pentacyclic skeleton fromPhlegmariurus phlegmaria.Tetrahedron Letters2020, 61 (2), 151381.

9. Zhang, Z.-J.; Morris-Natschke, S. L.; Cheng, Y.-Y.; Lee, K.-H.*; Li, R.-T.*, Development of anti-influenza agents from natural products.Medicinal Research Reviews2020, 40 (6), 2290-2338.

10. Zhang, Z.-J.; Li, G.-X.; Liu, D.; Chen, X.-Q.; Li, H.-M.; Li, R.-T.*, A novel pterocarpan derivative from the roots ofSophora flavescens.Natural Product Communications2020, 15 (10), 1934578X20964677.

11. Zhang, Z.-J.; Wang, C.; Wu, X.-D.; Huang, Y.; Zhou, W.-X.; Zhao, Q.-S.*, Phlegmadine A: aLycopodiumalkaloid with a unique cyclobutane ring fromPhlegmariurus phlegmaria.Journal of Organic Chemistry2019, 84 (17), 11301-11305.

12. Zhang, Z.-J.; Zhu, Q.-F.; Su, J.; Wu, X.-D.; Zhao, Q.-S.*, Lycoplanines B-D, threeLycopodiumalkaloids fromLycopodium complanatum.Natural Products and Bioprospecting2018, 8 (3), 177-182.

13. Zhang, Z.-J.; Qi, Y.-Y.; Wu, X.-D.; Su, J.; Zhao, Q.-S.*, Lycogladines A-H, fawcettimine-typeLycopodiumalkaloids fromLycopodium complanatumvar.glaucumChing.Tetrahedron2018, 74 (14), 1692-1697.

14. Zhang, Z.-J.; Nian, Y.; Zhu, Q.-F.; Li, X.-N.; Su, J.; Wu, X.-D.; Yang, J.; Zhao, Q.-S.*, Lycoplanine A, a C16NLycopodiumalkaloid with a 6/9/5 tricyclic skeleton fromLycopodium complanatum.Organic Letters2017, 19 (17), 4668-4671.

15. Zhang, Z.-J.; Du, R.-N.; He, J.; Wu, X.-D.; Li, Y.; Li, R.-T.*; Zhao, Q.-S.*, Three new monoterpenoid indole alkaloids from Vinca major.Journal of Asian Natural Products Research2016, 18 (4), 328-333.

16. Zhang, Z.-J.; Du, R.-N.; He, J.; Wu, X.-D.; Li, Y.; Li, R.-T.*; Zhao, Q.-S.*, Vinmajorines C – E, monoterpenoid indole alkaloids fromVinca major.Helvetica Chimica Acta2016, 99 (2), 157-160.

17. Zhang, Z.-J.; Yang, J.; He, J.; Wu, X.-D.; Shao, L.-D.; Li, Y.; Huang, S.-X.; Li, R.-T.*; Zhao, Q.-S.*, Vincamajorines A and B, monoterpenoid indole alkaloids with new carbon skeletons fromVinca major.Tetrahedron Letters2014, 55 (47), 6490-6494.

18. Zhang, Z.-J.; He, J.; Li, Y.; Wu, X.-D.; Gao, X.; Peng, L.-Y.; Cheng, X.; Li, R.-T.*; Zhao, Q.-S.*, Three new sesquiterpenes fromLaggera pterodonta.Helvetica Chimica Acta2013, 96 (4), 732-737.

五、 主持项目

1.国家自然科学基金委员会,地区科学基金项目, 31960092,三种槐属药用植物调控肿瘤相关巨噬细胞功能的化学物质基础研究, 38.0万元,在研,主持(2020.01-2023.12)

2.云南省科技厅科技计划,4066金沙“双一流”创建联合专项面上项目,202101BE070001-045,基于抗流感病毒药效物质基础的越南槐非药用部位药用价值评价,20.0万元,在研,主持(2021.12-2024.11)

3.4066金沙高层次人才引进项目, 80万元,进行中,主持(2021.08-2029.08)

4.中国博士后科学基金会,面上项目, 2019M653498,苦豆子发挥抗流感及抗炎的物质基础及分子机理研究, 8万元,结题,主持(2019.06-2020.06)

六、 联系方式

地址:昆明市呈贡区4066金沙(中国)有限公司(650500)

电话:15912198933

E-mail:zzj0121@126.com

版权所有© 4066金沙(中国)有限公司  地址:云南省昆明市呈贡区景明南路727号